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The E-Cigarette Experience: List of Studies Proving its Effectiveness to Help Quit Smoking

This comprehensive guide goes in-depth into the e-cigarette experience and its effectiveness in helping smokers quit. It is essential for readers who consider e-cigarettes an alternative to smoking or are curious about it. We will discuss studies that support e-cigarettes as an effective smoking cessation tool and provide expanded tips for a successful quitting journey.

Studies Supporting E-Cigarettes for Smoking Cessation

Numerous research efforts have demonstrated the efficacy of e-cigarettes in assisting smokers to either quit or decrease their tobacco use. Here are some of the key findings you need to know:

Public Health England’s Report

In 2015, Public Health England (PHE) released a pioneering report asserting that e-cigarettes were 95% less detrimental than conventional cigarettes. This assertion was derived from an extensive evaluation of the existing evidence, encompassing data on e-cigarette utilization, chemical makeup, and health consequences.

Some of the facts included in the report are as follows:

  • According to PHE, nearly 20,000 people in England successfully quit smoking each year with the help of e-cigarettes.
  • The report emphasized that e-cigarettes were not a gateway to smoking for young people, as most e-cigarette users were current or former smokers.
  • In addition to the 2015 report, PHE continued to review the evidence on e-cigarettes and their role in tobacco harm reduction.
  • In their 2018 evidence update, PHE maintained that e-cigarettes were significantly less harmful than smoking and that their use could support smokers quitting.
  • The report also found that thousands of smokers in England had incorrectly believed e-cigarettes were as harmful as traditional cigarettes, indicating a need for clearer public health messaging.

Cochrane Review

The 2020 Cochrane Review on e-cigarettes for smoking cessation comprehensively analyzed the available evidence. It included 50 studies involving a total of 12,430 participants, out of which 26 were randomized controlled trials (RCTs). The review aimed to determine the effectiveness and safety of e-cigarettes in helping smokers quit or reduce their tobacco use.

Below are some of the findings collected from the 2020 Cochrane study:

  • The analysis found that e-cigarettes containing nicotine were more effective for smoking cessation than nicotine replacement therapy (NRT), such as patches, gum, or e-cigarettes without nicotine.
  • Participants using nicotine e-cigarettes were 1.7 times more likely to quit smoking for at least six months than those using NRT.
  • In addition, the review found that e-cigarettes containing nicotine increased the quit rate by 10% compared to nicotine-free e-cigarettes.
  • The Cochrane Review also assessed the safety of e-cigarettes, finding that the reported side effects were generally mild and short-lived.
  • Common side effects included throat or mouth irritation, headache, and coughing.

However, the review noted that the long-term safety of e-cigarettes remains uncertain due to the limited data available.

The E3 Trial

The E3 Trial, conducted in 2021, was a large-scale, multi-center, randomized controlled trial investigating the effectiveness of e-cigarettes combined with behavioral support compared to nicotine replacement therapy (NRT) and behavioral support for smoking cessation.

Here are some vital facts worth stressing from the E3 trial:

  • The trial involved 1,836 participants from several countries, including the United Kingdom, New Zealand, and Australia.
  • Participants in the study were adult smokers seeking support to quit. They were randomly assigned to one of the two intervention groups: e-cigarettes plus behavioral support or NRT plus behavioral support.
  • The behavioral support provided in both groups included counseling sessions, self-help materials, and telephone support to assist with quitting smoking.
  • The study’s primary outcome was the self-reported continuous abstinence from smoking for six months.
  • The results showed that participants using e-cigarettes with behavioral support had higher quit rates at six months (23.7%) than those using NRT with behavioral support (16.7%).

The study also found that e-cigarette users reported lower levels of cravings and higher satisfaction with their chosen cessation method than NRT users.

Regarding safety, the E3 Trial found that e-cigarettes and NRT had similar rates of adverse events, most of which were mild and resolved without intervention. The study concluded that e-cigarettes combined with behavioral support could be a viable and effective option for smoking cessation, offering an alternative for smokers who have not succeeded with traditional NRT methods.


In conclusion, the growing body of evidence, including key studies such as Public Health England’s report, the Cochrane Review, and the E3 Trial, consistently supports the effectiveness of e-cigarettes as a smoking cessation tool. E-cigarettes have been shown to be significantly less harmful than traditional cigarettes and can help smokers quit or reduce their tobacco consumption.

Furthermore, e-cigarettes have been found to be more effective than nicotine replacement therapy in combination with behavioral support. While the long-term safety of e-cigarettes remains uncertain, the short-term side effects are generally mild and short-lived. It is crucial for public health authorities to provide clear and accurate information to smokers about the benefits and risks of e-cigarettes as a smoking cessation aid.

For those who have struggled with traditional cessation methods, e-cigarettes could be a viable and effective alternative on their journey to becoming smoke-free.

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